2 Matching Annotations
  1. Jul 2018
    1. On 2014 Dec 02, Walter Vogel commented:

      While this study suggested a strong inverse relationship between BCL11B phosphorylation and sumoylation, subsequent results (http://www.ncbi.nlm.nih.gov/pubmed/25423098) now reveal a complex pattern of multisite phosphorylation and dephosphorylation temporally linked to desumoylation and resumoylation. Using MRM (SRM) mass spectrometry we followed the site-specific phosphokinetics (18 sites) and sumoylation kinetics (one site, both SUMO1 and SUMO2/3) following cellular stimulation and found that phosphorylation and dephosphorylation was rapidly and simultaneously occurring on nearby sites. We concluded that Desumoylation and Resumoylation occur in different phospho-BCL11B contexts.


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  2. Feb 2018
    1. On 2014 Dec 02, Walter Vogel commented:

      While this study suggested a strong inverse relationship between BCL11B phosphorylation and sumoylation, subsequent results (http://www.ncbi.nlm.nih.gov/pubmed/25423098) now reveal a complex pattern of multisite phosphorylation and dephosphorylation temporally linked to desumoylation and resumoylation. Using MRM (SRM) mass spectrometry we followed the site-specific phosphokinetics (18 sites) and sumoylation kinetics (one site, both SUMO1 and SUMO2/3) following cellular stimulation and found that phosphorylation and dephosphorylation was rapidly and simultaneously occurring on nearby sites. We concluded that Desumoylation and Resumoylation occur in different phospho-BCL11B contexts.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.