On 2015 Mar 01, Joe Newton commented:

I'm an engineer experienced in simultaneous dynamic systems and not familiar with ALS. The findings of 'Regulation of Cellular Component Organization and Biogenesis', and in particular 'Actin Cytoskeleton', both suggest structural components of the plasma membrane are similar to psychiatric anomalies. These categories are expected to influence membrane stiffness and thus volume and/or myelination abnormalities in multiple neuropsychiatric diagnoses. The genetic and pathway based analyses of psychiatric anomalies have all been confounded by diagnostic (in the absence of biomarkers) and statistical uncertainty. Best wishes, Joe Ray Newton

On 2015 Mar 01, Joe Newton commented:

I'm an engineer experienced in simultaneous dynamic systems and not familiar with ALS. The findings of 'Regulation of Cellular Component Organization and Biogenesis', and in particular 'Actin Cytoskeleton', both suggest structural components of the plasma membrane are similar to psychiatric anomalies. These categories are expected to influence membrane stiffness and thus volume and/or myelination abnormalities in multiple neuropsychiatric diagnoses. The genetic and pathway based analyses of psychiatric anomalies have all been confounded by diagnostic (in the absence of biomarkers) and statistical uncertainty. Best wishes, Joe Ray Newton