On 2014 Mar 20, Pedro Reche commented:

We recognized that protein biosynthesis and degradation leaves an indelible trace in the distribution of viral-specific CD8 T cell epitopes throughout the proteomes. This trace led as to identify an ingenious and novel system to control protein expression based on early termination of protein translation. Virus simplicity demands simple solutions and this system explain why in viruses with a single CDS, the structural proteins required for viral assembly are always located at the n-terminal portion of the translated CDS (e.g. capsid proteins) while non-structural proteins are placed towards the c-terminus.

On 2014 Mar 20, Pedro Reche commented:

We recognized that protein biosynthesis and degradation leaves an indelible trace in the distribution of viral-specific CD8 T cell epitopes throughout the proteomes. This trace led as to identify an ingenious and novel system to control protein expression based on early termination of protein translation. Virus simplicity demands simple solutions and this system explain why in viruses with a single CDS, the structural proteins required for viral assembly are always located at the n-terminal portion of the translated CDS (e.g. capsid proteins) while non-structural proteins are placed towards the c-terminus.