On 2014 Aug 27, Jim Woodgett commented:

Non-competitive (with regard to ATP) inhibitors are an important addition to the arsenal of GSK-3 inhibitors (like TDZD). However, it should be noted that this analysis did not test GSK-3alpha (a highly structurally related kinase to GSK-3beta and the docking to the crystal structure was performed in silicon with no mutational verification. These pilot compounds are likely to be similarly potent against GSK-3alpha (as is TDZD and essentially all other small molecule GSK-3 inhibitors).

On 2014 Aug 27, Jim Woodgett commented:

Non-competitive (with regard to ATP) inhibitors are an important addition to the arsenal of GSK-3 inhibitors (like TDZD). However, it should be noted that this analysis did not test GSK-3alpha (a highly structurally related kinase to GSK-3beta and the docking to the crystal structure was performed in silicon with no mutational verification. These pilot compounds are likely to be similarly potent against GSK-3alpha (as is TDZD and essentially all other small molecule GSK-3 inhibitors).