2 Matching Annotations
  1. Jul 2018
    1. On 2014 Jul 27, David Keller commented:

      A prokinetic agent with a similar mechanism of action, cisapride, was withdrawn from the U.S. market due to its side-effect of electrocardiographic QT interval prolongation, which increases the risk of an often-fatal heart arrhythmia called torsade de pointes. Therefore, it is pertinent to ask what effect, if any, mosapride may have on the QT interval or other parameters of the ECG. In at least one animal model, the answer appears reassuring, with no QT prolongation noted.(1)

      Reference:

      1: Endo J, Nomura M, Morishita S, Uemura N, Inoue S, Kishi S, Kawaguchi R, Iga A, Ito S, Nakaya Y. Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. J Gastroenterol. 2002;37(11):888-95. PubMed PMID: 12483243.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.

  2. Feb 2018
    1. On 2014 Jul 27, David Keller commented:

      A prokinetic agent with a similar mechanism of action, cisapride, was withdrawn from the U.S. market due to its side-effect of electrocardiographic QT interval prolongation, which increases the risk of an often-fatal heart arrhythmia called torsade de pointes. Therefore, it is pertinent to ask what effect, if any, mosapride may have on the QT interval or other parameters of the ECG. In at least one animal model, the answer appears reassuring, with no QT prolongation noted.(1)

      Reference:

      1: Endo J, Nomura M, Morishita S, Uemura N, Inoue S, Kishi S, Kawaguchi R, Iga A, Ito S, Nakaya Y. Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. J Gastroenterol. 2002;37(11):888-95. PubMed PMID: 12483243.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.