On 2013 Jun 29, Rahul Bakshi commented:

The association of 'delayed parasite clearance' in response to artemisinin with a general mechanism like DNA repair suggests that Cambodian parasites of interest may simply be 'fitter'in terms of dealing with the DNA damage that accompanies any drug-induced death pathway. This gives rise to a couple of questions: 1) Would these parasites demonstrate delayed clearance when challenged with other drug classes? 2)Why is the parasite population structure in Cambodia still so heterogenous? One would (perhaps naively) expect the fitter population to take over. Is there a cost associated with these SNPs in other stages of the lifecycle? 3)Would the parasite population structure in Cambodia change if artemisinin pressure was withdrawn? Thoughts, anyone?

On 2013 Jun 29, Rahul Bakshi commented:

The association of 'delayed parasite clearance' in response to artemisinin with a general mechanism like DNA repair suggests that Cambodian parasites of interest may simply be 'fitter'in terms of dealing with the DNA damage that accompanies any drug-induced death pathway. This gives rise to a couple of questions: 1) Would these parasites demonstrate delayed clearance when challenged with other drug classes? 2)Why is the parasite population structure in Cambodia still so heterogenous? One would (perhaps naively) expect the fitter population to take over. Is there a cost associated with these SNPs in other stages of the lifecycle? 3)Would the parasite population structure in Cambodia change if artemisinin pressure was withdrawn? Thoughts, anyone?