On 2014 Aug 27, Ryan Radecki commented:

Post-publication commentary:

"The Latest Myth: Contrast-Induced Nephropathy?"

Here’s the simple explanation for why none of our observed treatments to prevent contrast-induced nephropathy – acetylcysteine, hydration, sodium bicarbonate – reliably work: CIN is a myth.

There’s a lot of observational literature evaluating the incidence of mild acute-kidney injury after iodinated contrast exposure – either CT scans or vascular procedures – and every study shows some increase in serum creatinine in a small, but significant, proportion of patients. But, as this study suggests, is this just random effects, a confounder from co-occurring medical illness, or true dose-dependent renal injury?

http://www.emlitofnote.com/2013/12/the-latest-myth-contrast-induced.html

On 2014 Aug 27, Ryan Radecki commented:

Post-publication commentary:

"The Latest Myth: Contrast-Induced Nephropathy?"

Here’s the simple explanation for why none of our observed treatments to prevent contrast-induced nephropathy – acetylcysteine, hydration, sodium bicarbonate – reliably work: CIN is a myth.

There’s a lot of observational literature evaluating the incidence of mild acute-kidney injury after iodinated contrast exposure – either CT scans or vascular procedures – and every study shows some increase in serum creatinine in a small, but significant, proportion of patients. But, as this study suggests, is this just random effects, a confounder from co-occurring medical illness, or true dose-dependent renal injury?

http://www.emlitofnote.com/2013/12/the-latest-myth-contrast-induced.html