On 2014 Jun 27, David Keller commented:

H2-water therapy improved Parkinson disease in this pilot study - can it be replicated?

The results of this small but apparently well-designed pilot study were very encouraging, and seemed to demonstrate in humans with Parkinson disease [PD] significant benefits from drinking water saturated with dissolved hydrogen gas (also called "H2-water"). H2-water is hypothesized to be an effective antioxidant in vivo, and has demonstrated benefits in animal models of PD (1,2,3). More than a year has elapsed since the publication of the provocative findings of this pilot study. We need a large clinical trial to either confirm or refute the benefits of H2-water in humans with PD.

References

1) Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett. 2009 Apr 3;453(2):81-5. doi: 10.1016/j.neulet.2009.02.016. Epub 2009 Feb 12.PubMed [citation] PMID: 19356598

2) Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One. 2009 Sep 30;4(9):e7247. doi: 10.1371/journal.pone.0007247.PubMed [citation] PMID: 19789628, PMCID: PMC2747267

3) Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. Sci Rep. 2013 Nov 20;3:3273. doi: 10.1038/srep03273.PubMed [citation] PMID: 24253616, PMCID: PMC4070541

On 2014 Jun 27, David Keller commented:

H2-water therapy improved Parkinson disease in this pilot study - can it be replicated?

The results of this small but apparently well-designed pilot study were very encouraging, and seemed to demonstrate in humans with Parkinson disease [PD] significant benefits from drinking water saturated with dissolved hydrogen gas (also called "H2-water"). H2-water is hypothesized to be an effective antioxidant in vivo, and has demonstrated benefits in animal models of PD (1,2,3). More than a year has elapsed since the publication of the provocative findings of this pilot study. We need a large clinical trial to either confirm or refute the benefits of H2-water in humans with PD.

References

1) Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett. 2009 Apr 3;453(2):81-5. doi: 10.1016/j.neulet.2009.02.016. Epub 2009 Feb 12.PubMed [citation] PMID: 19356598

2) Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One. 2009 Sep 30;4(9):e7247. doi: 10.1371/journal.pone.0007247.PubMed [citation] PMID: 19789628, PMCID: PMC2747267

3) Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice. Sci Rep. 2013 Nov 20;3:3273. doi: 10.1038/srep03273.PubMed [citation] PMID: 24253616, PMCID: PMC4070541