On 2015 May 12, Gareth Pryce commented:

There would appear to be a methodological flaw in this study which makes it's extrapolation to the human situation tenuous. Taken from this article http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397713 (Food & Drink intake of mouse)the food/fluid intake of a mouse (C57Bl/6 strain used in this study)is 4.4g/day and fluid = 6ml of fluid a day, this study used 1% salt in water = 1g in 100ml and 4% in food = 4g in 100g of food. I have calculated that on average the mice would ingest (before of course they got sick, when they wouldn't ingest any food or water) 236 mg/day for a 25g mouse = 236mg/25g = 9.44g/kg so 660g for a human ie over half a Kg of salt a day. The likelihood of any human ingesting this amount of salt is very unlikely.

Even doing a factor of ten 60g of salt which is 8 times a recommended limit of 8g/day. and twice the 35g/day found in some papers.

There was no dose response done in this paper, or repetition of the result reported. I am surprised that this was not picked up during the refereeing process.

These results need to be taken with a pinch of salt!

On 2015 May 12, Gareth Pryce commented:

There would appear to be a methodological flaw in this study which makes it's extrapolation to the human situation tenuous. Taken from this article http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397713 (Food & Drink intake of mouse)the food/fluid intake of a mouse (C57Bl/6 strain used in this study)is 4.4g/day and fluid = 6ml of fluid a day, this study used 1% salt in water = 1g in 100ml and 4% in food = 4g in 100g of food. I have calculated that on average the mice would ingest (before of course they got sick, when they wouldn't ingest any food or water) 236 mg/day for a 25g mouse = 236mg/25g = 9.44g/kg so 660g for a human ie over half a Kg of salt a day. The likelihood of any human ingesting this amount of salt is very unlikely.

Even doing a factor of ten 60g of salt which is 8 times a recommended limit of 8g/day. and twice the 35g/day found in some papers.

There was no dose response done in this paper, or repetition of the result reported. I am surprised that this was not picked up during the refereeing process.

These results need to be taken with a pinch of salt!