On 2013 Jun 14, Dita Gratzinger commented:

This single institution retrospective study provides needed information on the landscape of acute myeloid leukemia in children. Of note are significant numbers of children with favorable outcomes associated with recurrent translocations such as t(8;21)(q22;q22);RUNX1-RUNX1T1, or t(15;17)(q22;q12);PML-RARA, as well as myeloid leukemia associated with Down syndrome. Unfortunately similarly large groups of children have poor to very poor outcomes in the categories of acute myeloid leukemia with myelodysplasia-related changes and therapy-related acute myeloid leukemia. This study both confirms the relevance of categories in the WHO 2008 classification to childhood acute myeloid leukemias, and points to areas of need for improved therapy.

On 2013 Jun 14, Dita Gratzinger commented:

This single institution retrospective study provides needed information on the landscape of acute myeloid leukemia in children. Of note are significant numbers of children with favorable outcomes associated with recurrent translocations such as t(8;21)(q22;q22);RUNX1-RUNX1T1, or t(15;17)(q22;q12);PML-RARA, as well as myeloid leukemia associated with Down syndrome. Unfortunately similarly large groups of children have poor to very poor outcomes in the categories of acute myeloid leukemia with myelodysplasia-related changes and therapy-related acute myeloid leukemia. This study both confirms the relevance of categories in the WHO 2008 classification to childhood acute myeloid leukemias, and points to areas of need for improved therapy.