On 2013 Oct 28, DAVID SANDERS commented:

From "Covalent modifications of the ebola virus glycoprotein" Jeffers SA, 2002 "The conservation of a mucin-like region and its variability between isolates indicate that it is likely to play a critical role in the ecology and pathogenesis of the virus, factors which cannot be assessed in the pseudotype system. The probable surface exposure of the charged sugar moieties in this region may make it a dominant target for the humoral immune system. Indeed, protective monoclonal antibodies recognizing epitopes that lie between sequences that are likely to be modified by O-linked glycosylation have been identified. The toleration of the mucin-like domain for variations could allow the virus to readily escape immune recognition through mutations. Indeed, the protective monoclonal antibodies recognizing the Ebola virus Zaire GP O-linked glycosylation region have been shown to be specific for particular isolates Wilson JA, 2000.

On 2013 Oct 28, DAVID SANDERS commented:

From "Covalent modifications of the ebola virus glycoprotein" Jeffers SA, 2002 "The conservation of a mucin-like region and its variability between isolates indicate that it is likely to play a critical role in the ecology and pathogenesis of the virus, factors which cannot be assessed in the pseudotype system. The probable surface exposure of the charged sugar moieties in this region may make it a dominant target for the humoral immune system. Indeed, protective monoclonal antibodies recognizing epitopes that lie between sequences that are likely to be modified by O-linked glycosylation have been identified. The toleration of the mucin-like domain for variations could allow the virus to readily escape immune recognition through mutations. Indeed, the protective monoclonal antibodies recognizing the Ebola virus Zaire GP O-linked glycosylation region have been shown to be specific for particular isolates Wilson JA, 2000.