On 2013 Jun 19, Markus Meissner commented:

In this study Gaji et al. present a new methodology to indentify host cell factors that are involved in Toxoplasma gondii invasion. They performed a high throughput screen and identified several candidates, where the knockdown results in less efficient host cell invasion by this parasite. The authors speculate that six identified candidates affect parasite invasion by modifying actin dynamics. Although at this point no novel mechanistic concept can be presented, the results of this elegant screen will provide the field with novel ideas for future investigations of host cell factors that are involved during invasion by apicomplexan parasites. Currently our view of host cell invasion and the mechanisms involved during this process are challenged by intriguing results from several groups that do not fit the current models. Therefore this study is very timely and provides the field with a new resource for hypothesis driven follow up studies on some of the identified candidates.

On 2013 Jun 19, Markus Meissner commented:

In this study Gaji et al. present a new methodology to indentify host cell factors that are involved in Toxoplasma gondii invasion. They performed a high throughput screen and identified several candidates, where the knockdown results in less efficient host cell invasion by this parasite. The authors speculate that six identified candidates affect parasite invasion by modifying actin dynamics. Although at this point no novel mechanistic concept can be presented, the results of this elegant screen will provide the field with novel ideas for future investigations of host cell factors that are involved during invasion by apicomplexan parasites. Currently our view of host cell invasion and the mechanisms involved during this process are challenged by intriguing results from several groups that do not fit the current models. Therefore this study is very timely and provides the field with a new resource for hypothesis driven follow up studies on some of the identified candidates.