- Jul 2018
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europepmc.org europepmc.org
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On 2014 Jul 04, Christos Chinopoulos commented:
Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene
coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl Acad Sci
U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110, yielding itaconate. Itaconate is preferentially
used by succinyl CoA ligase forming itaconyl CoA, thus generating an accumulation of succinate when the ligase
operates towards succinyl CoA formation ADLER J, WANG SF, & Lardy HA (1957) The metabolism of itaconic acid by
liver mitochondria. J. Biol. Chem, 229, 865-879, and WANG SF, ADLER J, & Lardy HA (1961) The pathway of
itaconate metabolism by liver mitochondria. J. Biol. Chem, 236, 26-30.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
-
europepmc.org europepmc.org
-
On 2014 Jul 04, Christos Chinopoulos commented:
Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene
coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl Acad Sci
U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110, yielding itaconate. Itaconate is preferentially
used by succinyl CoA ligase forming itaconyl CoA, thus generating an accumulation of succinate when the ligase
operates towards succinyl CoA formation ADLER J, WANG SF, & Lardy HA (1957) The metabolism of itaconic acid by
liver mitochondria. J. Biol. Chem, 229, 865-879, and WANG SF, ADLER J, & Lardy HA (1961) The pathway of
itaconate metabolism by liver mitochondria. J. Biol. Chem, 236, 26-30.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
-