2 Matching Annotations
  1. Jul 2018
    1. On 2014 Jul 04, Christos Chinopoulos commented:

      Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene

      coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl Acad Sci

      U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110, yielding itaconate. Itaconate is preferentially

      used by succinyl CoA ligase forming itaconyl CoA, thus generating an accumulation of succinate when the ligase

      operates towards succinyl CoA formation ADLER J, WANG SF, & Lardy HA (1957) The metabolism of itaconic acid by

      liver mitochondria. J. Biol. Chem, 229, 865-879, and WANG SF, ADLER J, & Lardy HA (1961) The pathway of

      itaconate metabolism by liver mitochondria. J. Biol. Chem, 236, 26-30.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.

  2. Feb 2018
    1. On 2014 Jul 04, Christos Chinopoulos commented:

      Could it be that LPS-induced succinate over-production is due to itaconate formation? LPS induces Irg1, a gene

      coding for cis-aconitate decarboxylase, specifically expressed in cells of macrophage lineage Proc Natl Acad Sci

      U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110, yielding itaconate. Itaconate is preferentially

      used by succinyl CoA ligase forming itaconyl CoA, thus generating an accumulation of succinate when the ligase

      operates towards succinyl CoA formation ADLER J, WANG SF, & Lardy HA (1957) The metabolism of itaconic acid by

      liver mitochondria. J. Biol. Chem, 229, 865-879, and WANG SF, ADLER J, & Lardy HA (1961) The pathway of

      itaconate metabolism by liver mitochondria. J. Biol. Chem, 236, 26-30.


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.