On 2014 Feb 28, David Keller commented:

CoEnzyme Q10 supplements for MSA and, maybe, certain PD sub-types?

Ozawa commented that the results of this study suggest "that the oral supplementation of COQ10 may be helpful in treating patients who have MSA." (1)

Multiple-system atrophy (MSA) is a degenerative alpha-synucleinopathy, sharing some similar pathological findings and clinical symptoms with Parkinson's disease (PD) and dementia with Lewy bodies.

In the past, oral supplementation with coenzyme Q10 was postulated to be neuroprotective in PD, a hypothesis which has been set aside after disappointing clinical trial results.

If Ozawa's hypothesis that oral CoQ-10 supplementation may be helpful in MSA is proven correct, could it be that there is a sub-set of PD patients who might also benefit from oral CoQ-10 supplementation? Perhaps those PD patients who share certain clinical or pathological findings with MSA patients? Are there any plans for a clinical trial of CoQ-10 supplementation in MSA patients?

1. Ozawa T. The COQ2 mutations in Japanese multiple system atrophy: Impact on the pathogenesis and phenotypic variation. Mov Disord. 2013 Dec 27. doi: 10.1002/mds.25685. [Epub ahead of print] PubMed PMID: 24375810.

To facilitate discussion, I respectfully request the person who found this comment "not helpful" to state their reason

On 2014 Feb 28, David Keller commented:

CoEnzyme Q10 supplements for MSA and, maybe, certain PD sub-types?

Ozawa commented that the results of this study suggest "that the oral supplementation of COQ10 may be helpful in treating patients who have MSA." (1)

Multiple-system atrophy (MSA) is a degenerative alpha-synucleinopathy, sharing some similar pathological findings and clinical symptoms with Parkinson's disease (PD) and dementia with Lewy bodies.

In the past, oral supplementation with coenzyme Q10 was postulated to be neuroprotective in PD, a hypothesis which has been set aside after disappointing clinical trial results.

If Ozawa's hypothesis that oral CoQ-10 supplementation may be helpful in MSA is proven correct, could it be that there is a sub-set of PD patients who might also benefit from oral CoQ-10 supplementation? Perhaps those PD patients who share certain clinical or pathological findings with MSA patients? Are there any plans for a clinical trial of CoQ-10 supplementation in MSA patients?

1. Ozawa T. The COQ2 mutations in Japanese multiple system atrophy: Impact on the pathogenesis and phenotypic variation. Mov Disord. 2013 Dec 27. doi: 10.1002/mds.25685. [Epub ahead of print] PubMed PMID: 24375810.

To facilitate discussion, I respectfully request the person who found this comment "not helpful" to state their reason