On 2013 Nov 05, Allison Stelling commented:

The ECM section of this paper ((c) Tumor-stromal extra-cellular matrix-ECM-dependent interactions) lends weight to the idea that the ECM constituents of cellular secretions themselves may constitute a viable biomarker for "tumor-like" microenvironments.

Further physiochemical investigations into the unique biochemical phenotypes generated by tumor cells may be quite helpful for addressing issues with drug delivery, and provide new targets for drug design. (For example, the degree of cross-linking seen between collagens in the matrix would alter the density, possibly things like polarity/ability to H-bond, etc.)

On 2013 Nov 05, Allison Stelling commented:

The ECM section of this paper ((c) Tumor-stromal extra-cellular matrix-ECM-dependent interactions) lends weight to the idea that the ECM constituents of cellular secretions themselves may constitute a viable biomarker for "tumor-like" microenvironments.

Further physiochemical investigations into the unique biochemical phenotypes generated by tumor cells may be quite helpful for addressing issues with drug delivery, and provide new targets for drug design. (For example, the degree of cross-linking seen between collagens in the matrix would alter the density, possibly things like polarity/ability to H-bond, etc.)