On 2013 Dec 12, Ron Burk commented:

I wonder if the study had controlled for light exposure if it would have found what separated those who experienced benefits from those who don't. My suspicion is that AIs (whose side-effects closely mimic RA) have the same (poorly understood) relation to melatonin as RA does, and they are effectively inducing a form of RA. My hypothesis is that decreased estrogen in the pineal gland decreases the effectiveness of light-induced melatonin suppression, leading to auto-immune effects, providing a unified explanation for the joint pain of AIs and perimenopause. The solution being to get the patient's eyes into bright outdoor sunlight for as many hours each day as possible and try to restore a normal melatonin cycle. Burk R, 2008

On 2013 Dec 12, Ron Burk commented:

I wonder if the study had controlled for light exposure if it would have found what separated those who experienced benefits from those who don't. My suspicion is that AIs (whose side-effects closely mimic RA) have the same (poorly understood) relation to melatonin as RA does, and they are effectively inducing a form of RA. My hypothesis is that decreased estrogen in the pineal gland decreases the effectiveness of light-induced melatonin suppression, leading to auto-immune effects, providing a unified explanation for the joint pain of AIs and perimenopause. The solution being to get the patient's eyes into bright outdoor sunlight for as many hours each day as possible and try to restore a normal melatonin cycle. Burk R, 2008