On 2014 Aug 18, David Keller commented:

Ibuprofen, but not other NSAID's, is associated with decreased risk of Parkinson's disease

Ibuprofen use has also been observed to be strongly associated with a lower risk of incident Parkinson's disease (1). Other NSAID's, such as naproxen, have not showed any such apparent protective effect (2). Given that long-term use of NSAID's "such as ibuprofen" has been observed to be associated with "reduced risk and delayed onset of Alzheimer's disease", I would be cautious about substituting a different NSAID, such as flurbiprofen, unless it has also demonstrated the same associations with reduced Alzheimer's risk, because the epidemiological studies of NSAID use and Parkinson's risk have indicated that, when it comes to the risk of neurological degeneration, different NSAID's can have vastly different effects.

References

1: Gao X, Chen H, Schwarzschild MA, Ascherio A. Use of ibuprofen and risk of Parkinson disease. Neurology. 2011 Mar 8;76(10):863-9. doi: 10.1212/WNL.0b013e31820f2d79. Epub 2011 Mar 2. PubMed PMID: 21368281; PubMed Central PMCID: PMC3059148.

2: Driver JA, Logroscino G, Lu L, Gaziano JM, Kurth T. Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study. BMJ. 2011 Jan 20;342:d198. doi: 10.1136/bmj.d198. PubMed PMID: 21252104; PubMed Central PMCID: PMC3023971.

On 2014 Aug 18, David Keller commented:

Ibuprofen, but not other NSAID's, is associated with decreased risk of Parkinson's disease

Ibuprofen use has also been observed to be strongly associated with a lower risk of incident Parkinson's disease (1). Other NSAID's, such as naproxen, have not showed any such apparent protective effect (2). Given that long-term use of NSAID's "such as ibuprofen" has been observed to be associated with "reduced risk and delayed onset of Alzheimer's disease", I would be cautious about substituting a different NSAID, such as flurbiprofen, unless it has also demonstrated the same associations with reduced Alzheimer's risk, because the epidemiological studies of NSAID use and Parkinson's risk have indicated that, when it comes to the risk of neurological degeneration, different NSAID's can have vastly different effects.

References

1: Gao X, Chen H, Schwarzschild MA, Ascherio A. Use of ibuprofen and risk of Parkinson disease. Neurology. 2011 Mar 8;76(10):863-9. doi: 10.1212/WNL.0b013e31820f2d79. Epub 2011 Mar 2. PubMed PMID: 21368281; PubMed Central PMCID: PMC3059148.

2: Driver JA, Logroscino G, Lu L, Gaziano JM, Kurth T. Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study. BMJ. 2011 Jan 20;342:d198. doi: 10.1136/bmj.d198. PubMed PMID: 21252104; PubMed Central PMCID: PMC3023971.