On 2014 Feb 03, Adam VanWert commented:

I am happy to see that you cited our work on OAT3 and beta-lactam antibiotics (Wolman et al.). It's nice to see that you looked at overall renal clearance and its correlation with physicochemical properties of small molecules. Although your conclusions about interactions with OATs not being a good predictor of renal clearance is accurate, I still see the value in targeting an OAT. If your therapeutic target is within renal epithelial cells, then targeting an OAT would be a very sound strategy, especially because of the increased likelihood of coming back in through reabsorption (a second chance at interacting with the target). Perhaps as important would be to understand how to avoid an interaction with an OAT, to avoid renal epithelial accumulation.

On 2014 Feb 03, Adam VanWert commented:

I am happy to see that you cited our work on OAT3 and beta-lactam antibiotics (Wolman et al.). It's nice to see that you looked at overall renal clearance and its correlation with physicochemical properties of small molecules. Although your conclusions about interactions with OATs not being a good predictor of renal clearance is accurate, I still see the value in targeting an OAT. If your therapeutic target is within renal epithelial cells, then targeting an OAT would be a very sound strategy, especially because of the increased likelihood of coming back in through reabsorption (a second chance at interacting with the target). Perhaps as important would be to understand how to avoid an interaction with an OAT, to avoid renal epithelial accumulation.