- Jul 2018
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europepmc.org europepmc.org
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On 2015 Mar 31, Stuart RAY commented:
The middle part of figure 2, showing the T cell interacting with the FDC, is clearly wrong. FDC do not present antigens to T cells, and T cells do not provide help to FDC. Myeloid DC, which are from a completely distinct lineage from FDC (which are mesenchymal in origin). I think the artist conflated FDC with mDC. The T follicular helper (Tfh) cell should be interacting directly with the B cell, stimulating somatic hypermutation and/or class switching. The B cell will interact with an FDC, which will present trapped antigen and provide trophic signals. These are important concepts in understanding T cell dependent humoral immunity.
This search provides some excellent reviews, including this wonderful review in Nat Rev Immunol (not free): Kurosaki T, 2015
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2015 Mar 31, Stuart RAY commented:
The middle part of figure 2, showing the T cell interacting with the FDC, is clearly wrong. FDC do not present antigens to T cells, and T cells do not provide help to FDC. Myeloid DC, which are from a completely distinct lineage from FDC (which are mesenchymal in origin). I think the artist conflated FDC with mDC. The T follicular helper (Tfh) cell should be interacting directly with the B cell, stimulating somatic hypermutation and/or class switching. The B cell will interact with an FDC, which will present trapped antigen and provide trophic signals. These are important concepts in understanding T cell dependent humoral immunity.
This search provides some excellent reviews, including this wonderful review in Nat Rev Immunol (not free): Kurosaki T, 2015
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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