On 2014 Feb 27, FREDERICK DOMANN commented:

These interesting findings support and extend prior work by the same group (PMID: 16170370) and add pancreatic cancer to the growing list of malignancies where alterations in EcSOD expression can affect malignant phenotype (see also PMIDs: 23318435, 22064654, and 19602586). Nevertheless, Figure 7D unfortunately omits an important node in the signaling pathway between superoxide and HIF-1a; that is the effector molecule, the HIF-1 prolyl hydroxylases 1-3 (PHD1-3) which are the direct targets inhibited by superoxide (www.dovepress.com/getfile.php?fileID=17843). Conversely, and logically then, elevated SOD activity inhibits the inactivation of PHD family enzymes and suppresses the hypoxic induction of HIF-1a.

On 2014 Feb 27, FREDERICK DOMANN commented:

These interesting findings support and extend prior work by the same group (PMID: 16170370) and add pancreatic cancer to the growing list of malignancies where alterations in EcSOD expression can affect malignant phenotype (see also PMIDs: 23318435, 22064654, and 19602586). Nevertheless, Figure 7D unfortunately omits an important node in the signaling pathway between superoxide and HIF-1a; that is the effector molecule, the HIF-1 prolyl hydroxylases 1-3 (PHD1-3) which are the direct targets inhibited by superoxide (www.dovepress.com/getfile.php?fileID=17843). Conversely, and logically then, elevated SOD activity inhibits the inactivation of PHD family enzymes and suppresses the hypoxic induction of HIF-1a.