On 2014 Feb 27, guoan zhang commented:

axl and Tyro3 and Mer are important regulator of natural killer cell maturationCaraux A, 2006, and now those receptors are revealed to be players in the regulation of NK cells function in tumor immunology.it seems tumor ,through gas6 which could be secreted by tumor cells or stromal cells , suppressed the function of NK cells.and cbl-b takes a important role in gas6/TAM-mediated NK cells malfunction. and more important, the authors found a TAM kinase inhibitor and warfarin exerts anti-metastatic activity in mice via Cbl-b/TAM receptors in NK cells, suggesting possible clinical use.

On 2014 Feb 27, guoan zhang commented:

axl and Tyro3 and Mer are important regulator of natural killer cell maturationCaraux A, 2006, and now those receptors are revealed to be players in the regulation of NK cells function in tumor immunology.it seems tumor ,through gas6 which could be secreted by tumor cells or stromal cells , suppressed the function of NK cells.and cbl-b takes a important role in gas6/TAM-mediated NK cells malfunction. and more important, the authors found a TAM kinase inhibitor and warfarin exerts anti-metastatic activity in mice via Cbl-b/TAM receptors in NK cells, suggesting possible clinical use.