On 2014 Jun 05, Bruce Hope commented:

I expect that different afferents carry different types of information to the accumbens shell. Some brain areas can carry concrete information that does not vary too much between the two environmental contexts used in the above experiments (e.g., many physical attributes are relatively similar), so you might expect similar ensembles to be activated in these brain areas. Meanwhile other brain areas such as vmPFC may carry the more abstract 'meaning' of the context, which is not as dependent on the overall similarity of the concrete physical attributes but important for deciding to lever press, so you might expect very different ensembles to be activated in these brain areas. Overall its an empirical question and based on the literature, the hippocampus would be an interesting place to use Daun02 in the context-induced reinstatement model.

On 2014 May 30, Alejandro Higuera-Matas commented:

A really interesting piece of work, I wonder what the results would be like if the same experiment was performed in the hippocampus.

On 2014 May 30, Alejandro Higuera-Matas commented:

A really interesting piece of work, I wonder what the results would be like if the same experiment was performed in the hippocampus.

On 2014 Jun 05, Bruce Hope commented:

I expect that different afferents carry different types of information to the accumbens shell. Some brain areas can carry concrete information that does not vary too much between the two environmental contexts used in the above experiments (e.g., many physical attributes are relatively similar), so you might expect similar ensembles to be activated in these brain areas. Meanwhile other brain areas such as vmPFC may carry the more abstract 'meaning' of the context, which is not as dependent on the overall similarity of the concrete physical attributes but important for deciding to lever press, so you might expect very different ensembles to be activated in these brain areas. Overall its an empirical question and based on the literature, the hippocampus would be an interesting place to use Daun02 in the context-induced reinstatement model.