On 2015 Mar 29, Geriatric Medicine Journal Club commented:

This is an RCT of Droxidopa for neurogenic orthostatic hypotension. This article was critically appraised at the March 2015 Geriatric Medicine Journal Club (follow #GeriMedJC on Twitter). The full discussion can be found at: http://gerimedjc.blogspot.com/2015/03/gerimedjc-march-27-2015.html?spref=tw Concerns raised included the use of an optimization phase for recruitment into the randomization as this strategy selects individuals who tolerate and respond to the medication. In addition, there was a significant effect noted in the placebo group. Nevertheless, this was an important study addressing some disabling symptoms experienced by those with neurogenic orthostatic hypotension as defined by the Orthostatic Hypotension Questionnaire.

On 2015 Mar 29, Geriatric Medicine Journal Club commented:

This is an RCT of Droxidopa for neurogenic orthostatic hypotension. This article was critically appraised at the March 2015 Geriatric Medicine Journal Club (follow #GeriMedJC on Twitter). The full discussion can be found at: http://gerimedjc.blogspot.com/2015/03/gerimedjc-march-27-2015.html?spref=tw Concerns raised included the use of an optimization phase for recruitment into the randomization as this strategy selects individuals who tolerate and respond to the medication. In addition, there was a significant effect noted in the placebo group. Nevertheless, this was an important study addressing some disabling symptoms experienced by those with neurogenic orthostatic hypotension as defined by the Orthostatic Hypotension Questionnaire.