On 2014 Aug 24, David Keller commented:

Please see the response posted on the BMJ website by Dr. Yedy Israel, who explains why caution must be used in projecting the results of this study to persons with wild-type genes for alcohol dehydrogenase. The effects of ethanol consumption on normals can only be determined by studying normals. The consistently-observed minimum risk for cardiovascular disease in normals occurs with a chronic daily ingestion of about 1 to 2 ounces of ethanol per day (1), the so-called "J-shaped curve".

Reference

1: O'Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJ, Lavie CJ. Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clin Proc. 2014 Mar;89(3):382-93. doi: 10.1016/j.mayocp.2013.11.005. Review. PubMed PMID: 24582196.

On 2014 Aug 24, David Keller commented:

Please see the response posted on the BMJ website by Dr. Yedy Israel, who explains why caution must be used in projecting the results of this study to persons with wild-type genes for alcohol dehydrogenase. The effects of ethanol consumption on normals can only be determined by studying normals. The consistently-observed minimum risk for cardiovascular disease in normals occurs with a chronic daily ingestion of about 1 to 2 ounces of ethanol per day (1), the so-called "J-shaped curve".

Reference

1: O'Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJ, Lavie CJ. Alcohol and cardiovascular health: the dose makes the poison…or the remedy. Mayo Clin Proc. 2014 Mar;89(3):382-93. doi: 10.1016/j.mayocp.2013.11.005. Review. PubMed PMID: 24582196.