On 2014 Sep 04, Kenneth Witwer commented:

This review covers an important area of research, as saliva is obtained non-invasively and extracellular vesicles including exosomes may be enriched in useful biomarkers. Unfortunately, several apparent errors are repeated throughout the review.

-The type of extracellular vesicle known as an "exosome" is not the same entity as the nucleic acid processing complex of the same name. A confusion of the two seems evident here. Readers will need to consult the sources to determine what information is and is not relevant to extracellular vesicles.

-Intra- and intercellular vesicle trafficking are also conflated, with the Suedhof/Schekman/Rothman Nobel Prize research described as focused on exosomes. Secretory and secreted vesicles are certainly related, but they are distinct.

On 2014 Sep 04, Kenneth Witwer commented:

This review covers an important area of research, as saliva is obtained non-invasively and extracellular vesicles including exosomes may be enriched in useful biomarkers. Unfortunately, several apparent errors are repeated throughout the review.

-The type of extracellular vesicle known as an "exosome" is not the same entity as the nucleic acid processing complex of the same name. A confusion of the two seems evident here. Readers will need to consult the sources to determine what information is and is not relevant to extracellular vesicles.

-Intra- and intercellular vesicle trafficking are also conflated, with the Suedhof/Schekman/Rothman Nobel Prize research described as focused on exosomes. Secretory and secreted vesicles are certainly related, but they are distinct.