- Jul 2018
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europepmc.org europepmc.org
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On 2015 Feb 06, Pavel Baranov commented:
This paper provides an invaluable dataset of context dependent translation initiation start (TIS) efficiency. While the optimal (Kozak) TIS context has been determined a long time ago, estimating the power of individual TIS based on the contexts was usually qualitative, at best it was based on position weight matrices where the weight of each individual nucleotide was taken into account independently of other nucleotides. By systematically randomizing the context surrounding AUG codons Noderer et al measured TIS efficiencies of all 11-mers containing AUG codons. The dataset is available in Supplementary Table 2.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
-
europepmc.org europepmc.org
-
On 2015 Feb 06, Pavel Baranov commented:
This paper provides an invaluable dataset of context dependent translation initiation start (TIS) efficiency. While the optimal (Kozak) TIS context has been determined a long time ago, estimating the power of individual TIS based on the contexts was usually qualitative, at best it was based on position weight matrices where the weight of each individual nucleotide was taken into account independently of other nucleotides. By systematically randomizing the context surrounding AUG codons Noderer et al measured TIS efficiencies of all 11-mers containing AUG codons. The dataset is available in Supplementary Table 2.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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