On 2014 Sep 06, Ryan Radecki commented:

Post-publication commentary:

"Early P2Y12 Antagonists Just Don't Seem Useful"

When undergoing an early invasive strategy for myocardial infarction, the guidelines and trials typically support dual platelet inhibition. Most commonly, this regimen consists of aspirin and clopidogrel. However, the P2Y12 receptor antagonists ticagrelor and prasugrel have been promoted as options due to incremental increased platelet inhibition over clopidogrel. The theoretical benefits of early dual platelet inhibition include spontaneous lysis and prevention of re-thrombosis, as well as decreased early in-stent thrombosis. Unfortunately, the ACCOAST trial demonstrated early prasugrel was associated only with increased bleeding and no associated cardiovascular endpoint benefits.

Now we have ATLANTIC, with a similar treatment strategy, utilizing ticagrelor.

Which is also negative.

http://www.emlitofnote.com/2014/09/early-p2y12-antagonists-just-dont-seem.html

On 2014 Sep 06, Ryan Radecki commented:

Post-publication commentary:

"Early P2Y12 Antagonists Just Don't Seem Useful"

When undergoing an early invasive strategy for myocardial infarction, the guidelines and trials typically support dual platelet inhibition. Most commonly, this regimen consists of aspirin and clopidogrel. However, the P2Y12 receptor antagonists ticagrelor and prasugrel have been promoted as options due to incremental increased platelet inhibition over clopidogrel. The theoretical benefits of early dual platelet inhibition include spontaneous lysis and prevention of re-thrombosis, as well as decreased early in-stent thrombosis. Unfortunately, the ACCOAST trial demonstrated early prasugrel was associated only with increased bleeding and no associated cardiovascular endpoint benefits.

Now we have ATLANTIC, with a similar treatment strategy, utilizing ticagrelor.

Which is also negative.

http://www.emlitofnote.com/2014/09/early-p2y12-antagonists-just-dont-seem.html