On 2016 Jun 03, Ewen Gallagher commented:

This work analyses the MEKK1 (encoded by Map3k1) PHD motif genetically and by protein array substrate screening. Shows an important role for the MEKK1 PHD motif in TGF-β cytokine signaling and demonstrates how PHD ubiquitination can influence TAK1 signal transduction. Shows genetically by knockin mutation (Map3k1^mPHD allele) that MEKK1 is important for stem cell MAPK signaling, differentiation and tumorigenesis. Reports phenotypes of Map3k1^mPHD/+ mice. A review is also published for this work (1). Other recent works looking at MEKK1 activation by cytokines and hyperosmotic stress (2-3). A short review is available relating to this work (4).

Related work. (1). Suddason T, Gallagher E. A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1. Cell Death Differ 2015. (2). Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008; 321:663-8. (3). Steed E, Elbediwy A, Vacca B, Dupasquier S, Hemkemeyer SA, Suddason T, Costa AC, Beaudry JB, Zihni C, Gallagher E, et al. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. The Journal of cell biology 2014; 204:821-38. (4). Gallagher E, Suddason T. The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling. Molecular & cellular oncology 2015; 2:e980659.

On 2016 Jun 03, Ewen Gallagher commented:

This work analyses the MEKK1 (encoded by Map3k1) PHD motif genetically and by protein array substrate screening. Shows an important role for the MEKK1 PHD motif in TGF-β cytokine signaling and demonstrates how PHD ubiquitination can influence TAK1 signal transduction. Shows genetically by knockin mutation (Map3k1^mPHD allele) that MEKK1 is important for stem cell MAPK signaling, differentiation and tumorigenesis. Reports phenotypes of Map3k1^mPHD/+ mice. A review is also published for this work (1). Other recent works looking at MEKK1 activation by cytokines and hyperosmotic stress (2-3). A short review is available relating to this work (4).

Related work. (1). Suddason T, Gallagher E. A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1. Cell Death Differ 2015. (2). Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008; 321:663-8. (3). Steed E, Elbediwy A, Vacca B, Dupasquier S, Hemkemeyer SA, Suddason T, Costa AC, Beaudry JB, Zihni C, Gallagher E, et al. MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival. The Journal of cell biology 2014; 204:821-38. (4). Gallagher E, Suddason T. The PHD motif of Map3k1 activates cytokine-dependent MAPK signaling. Molecular & cellular oncology 2015; 2:e980659.