On 2014 Oct 21, Bertie Gottgens commented:

One point worth making may be that the studies reported here were presumably done under pathogen-free conditions, and in the absence of predators or any other environmental stresses. "Normal" hemaopoiesis in the real world may therefore have to call on blood production from the traditional 'transplantation HSCs' more often than is suggested here.

On 2014 Oct 21, Bertie Gottgens commented:

One point worth making may be that the studies reported here were presumably done under pathogen-free conditions, and in the absence of predators or any other environmental stresses. "Normal" hemaopoiesis in the real world may therefore have to call on blood production from the traditional 'transplantation HSCs' more often than is suggested here.