On 2014 Dec 02, Alison Harrill commented:

This is a much-needed review of mechanisms of acetaminophen toxicity as they relate to pediatric populations. Thank you for citing our paper in which we first identified a pharmacogenetic risk allele in CD44 in a genetically diverse mouse population and then subsequently validated the finding in two independent clinical trial cohorts. In those studies, sensitive subjects exhibited sub-acute elevations in ALT due to acetaminophen exposure at the maximum recommended therapeutic dose (which has since been lowered). Court et al. examined acetaminophen-induced acute liver failure cases and found indications that the same polymorphism in CD44 was enriched in cases of chronic acetaminophen use versus controls (PMID:24104197). To my knowledge, enrichment of this polymorphism in pediatric cases has not been evaluated.

On 2014 Dec 02, Alison Harrill commented:

This is a much-needed review of mechanisms of acetaminophen toxicity as they relate to pediatric populations. Thank you for citing our paper in which we first identified a pharmacogenetic risk allele in CD44 in a genetically diverse mouse population and then subsequently validated the finding in two independent clinical trial cohorts. In those studies, sensitive subjects exhibited sub-acute elevations in ALT due to acetaminophen exposure at the maximum recommended therapeutic dose (which has since been lowered). Court et al. examined acetaminophen-induced acute liver failure cases and found indications that the same polymorphism in CD44 was enriched in cases of chronic acetaminophen use versus controls (PMID:24104197). To my knowledge, enrichment of this polymorphism in pediatric cases has not been evaluated.