On 2015 Jan 07, Mohammad Salman commented:

I'm surprised by the findings of this paper since several authors have reported antiinflammatory effects of Thymoquinone and inhibition of COX-2 and PGE2 via Thymoquinone. See:

1: Kundu JK, Liu L, Shin JW, Surh YJ. Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo. Biochem Biophys Res Commun. 2013 Sep 6;438(4):721-7. doi: 10.1016/j.bbrc.2013.07.110. Epub 2013 Aug 1. PubMed PMID: 23911786.

2: Al Wafai RJ. Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats. Pancreas. 2013 Jul;42(5):841-9. doi: 10.1097/MPA.0b013e318279ac1c. PubMed PMID: 23429494.

3: El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett. 2006 Jul 15;106(1):72-81. Epub 2006 May 22. PubMed PMID: 16762422.

4: Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med. 2005 Aug;71(8):739-42. PubMed PMID: 16142638.

On 2015 Jan 07, Mohammad Salman commented:

I'm surprised by the findings of this paper since several authors have reported antiinflammatory effects of Thymoquinone and inhibition of COX-2 and PGE2 via Thymoquinone. See:

1: Kundu JK, Liu L, Shin JW, Surh YJ. Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo. Biochem Biophys Res Commun. 2013 Sep 6;438(4):721-7. doi: 10.1016/j.bbrc.2013.07.110. Epub 2013 Aug 1. PubMed PMID: 23911786.

2: Al Wafai RJ. Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats. Pancreas. 2013 Jul;42(5):841-9. doi: 10.1097/MPA.0b013e318279ac1c. PubMed PMID: 23429494.

3: El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett. 2006 Jul 15;106(1):72-81. Epub 2006 May 22. PubMed PMID: 16762422.

4: Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med. 2005 Aug;71(8):739-42. PubMed PMID: 16142638.