On 2015 Jan 12, Larry Parnell commented:

This paper was my selection for Paper of the Week for 1-5 Dec 2014.

This is highly important work and the conclusions drawn are valuable and applicable to many areas of genetic research into complex phenotypes. It is great to see scientists of this stature adding important insight into the role of GxEs, especially in terms of influence on gene expression.

I don't feel that the relationship described in this paper for ADIPOQ is so meaningful as the variant described is not in high LD in most populations with the ADIPOQ variants that support known GxE interactions for cardiometabolic phenotypes. See http://www.biodatamining.org/content/7/1/21 Nonetheless, there is also in the BioData Mining article a list of GxEs described for UCP2, which does have evidence in this report above.

On 2015 Jan 12, Larry Parnell commented:

This paper was my selection for Paper of the Week for 1-5 Dec 2014.

This is highly important work and the conclusions drawn are valuable and applicable to many areas of genetic research into complex phenotypes. It is great to see scientists of this stature adding important insight into the role of GxEs, especially in terms of influence on gene expression.

I don't feel that the relationship described in this paper for ADIPOQ is so meaningful as the variant described is not in high LD in most populations with the ADIPOQ variants that support known GxE interactions for cardiometabolic phenotypes. See http://www.biodatamining.org/content/7/1/21 Nonetheless, there is also in the BioData Mining article a list of GxEs described for UCP2, which does have evidence in this report above.