On 2015 Mar 17, Alan Taylor commented:

This confirms work done to determine causes of OA in elderly patients. Aromatase deficiency is a key contributor to OA. Not only is it responsible for the final step in the synthesis of estrogen from androstendione but also converts testosterone to estrogen in males. The estrogen acts on two E receptors in female bone cells/ in males there is one androgen receptor and one estrogen receptor. These are a essential for bone health and maintenance. In the genome wide study under expression of CYP19 gene that codes for aromatase was evident in most cases. Severe OA in a male has been successfully treated for 15 years using a low dose of transdermal estrogen. This effect has been shown to be reversible It takes 6 to 8 weeks for the treatment to reverse the OA. Discontinuation causes OA to redevelop after 6-8 weeks. Recommencement again reverses the OA to give no symptoms whatsoever. Aromatase inhibitors will obviously prevent the two E receptors in the osteocytes from working. In males testosterone deficiency also will prevent the aromatase from catalysing the formation of estrogen.

On 2015 Mar 17, Alan Taylor commented:

This confirms work done to determine causes of OA in elderly patients. Aromatase deficiency is a key contributor to OA. Not only is it responsible for the final step in the synthesis of estrogen from androstendione but also converts testosterone to estrogen in males. The estrogen acts on two E receptors in female bone cells/ in males there is one androgen receptor and one estrogen receptor. These are a essential for bone health and maintenance. In the genome wide study under expression of CYP19 gene that codes for aromatase was evident in most cases. Severe OA in a male has been successfully treated for 15 years using a low dose of transdermal estrogen. This effect has been shown to be reversible It takes 6 to 8 weeks for the treatment to reverse the OA. Discontinuation causes OA to redevelop after 6-8 weeks. Recommencement again reverses the OA to give no symptoms whatsoever. Aromatase inhibitors will obviously prevent the two E receptors in the osteocytes from working. In males testosterone deficiency also will prevent the aromatase from catalysing the formation of estrogen.