On 2015 Jan 22, Larry Parnell commented:

This paper was my selection for Paper of the Week for 12-16 Jan 2015.

We have it rather interesting to map onto the network described in this article (Fig 2) those genes carrying variants that associate with obesity anthropometrics. Some regions of the network are sparsely populated or entirely devoid of such obesity GWAS genes, while others have a great concentration of such genes.

We were surprised not to see FTO or extracellular remodeling genes/proteins displayed in this network. The FTO/IRX3 locus has much evidence linking it to obesity. As adipose expands, much remodeling of the extracellular matrix takes place.

On 2015 Jan 22, Larry Parnell commented:

This paper was my selection for Paper of the Week for 12-16 Jan 2015.

We have it rather interesting to map onto the network described in this article (Fig 2) those genes carrying variants that associate with obesity anthropometrics. Some regions of the network are sparsely populated or entirely devoid of such obesity GWAS genes, while others have a great concentration of such genes.

We were surprised not to see FTO or extracellular remodeling genes/proteins displayed in this network. The FTO/IRX3 locus has much evidence linking it to obesity. As adipose expands, much remodeling of the extracellular matrix takes place.