- Jul 2018
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europepmc.org europepmc.org
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On 2014 Dec 10, Jim Woodgett commented:
There is no direct evidence in this paper that the effects of lithium on kidney function are specifically via GSK-3beta. The GSK-3alpha isoform, which was not investigated, is equally inhibited by this ion and the following statement is erroneous: "lithium, a selective inhibitor of GSK3β". As an aside, dominant negative GSK-3beta (kinase-dead), interferes with both GSK-3alpha and beta.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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On 2014 Dec 10, Jim Woodgett commented:
There is no direct evidence in this paper that the effects of lithium on kidney function are specifically via GSK-3beta. The GSK-3alpha isoform, which was not investigated, is equally inhibited by this ion and the following statement is erroneous: "lithium, a selective inhibitor of GSK3β". As an aside, dominant negative GSK-3beta (kinase-dead), interferes with both GSK-3alpha and beta.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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