On 2015 Apr 02, University of Lausanne Genomics, Ecology and Evolution Journal Club commented:

The article nicely highlights the need for a reference genome panel consisting of African variants and understanding African population history. This is a summary of the discussion at our journal club. Gurdasani et al. offer evidence for B the antu expansion, although the sample distribution came mostly from the coast rather then inside of the African continent where the Bantu expansion occurred. Moreover, the article lacks discussion of the gene flow effects other then the impact of Euroasian admixture on the differentiation among the African populations. It would be interesting to see are some effects due to allele surfing or allele fixation. In the article, the highest proportion of Euroasian ancestry is observed in the Ethiopian population. The authors hypothesize that Euroasian ancestry is responsible for the differentiation in African populations, rather than adaptation to selective forces. But, the highly differentiated SNPs between Euroasian and African populations showed evidence of differentiation within genes of malaria susceptibility and osmoregulation, which makes the previous statement imprecise. Also, the results of population admixture shows an overlap both in Euroasian and HG ancestry in East Africa without any further explanation of how it happened. The last part of the article is probably the most valuable one, since it shows the improvement of imputation accuracy of African populations variants by using different reference genome panel. Although finding the optimal array design for capturing most of African variation is admirable, in the current state of sequencing technology it might not be necessary anymore. A final remark is that the visualization of the results in extended and supplementary data was sometimes hard to decipher.

On 2015 Apr 02, University of Lausanne Genomics, Ecology and Evolution Journal Club commented:

The article nicely highlights the need for a reference genome panel consisting of African variants and understanding African population history. This is a summary of the discussion at our journal club. Gurdasani et al. offer evidence for B the antu expansion, although the sample distribution came mostly from the coast rather then inside of the African continent where the Bantu expansion occurred. Moreover, the article lacks discussion of the gene flow effects other then the impact of Euroasian admixture on the differentiation among the African populations. It would be interesting to see are some effects due to allele surfing or allele fixation. In the article, the highest proportion of Euroasian ancestry is observed in the Ethiopian population. The authors hypothesize that Euroasian ancestry is responsible for the differentiation in African populations, rather than adaptation to selective forces. But, the highly differentiated SNPs between Euroasian and African populations showed evidence of differentiation within genes of malaria susceptibility and osmoregulation, which makes the previous statement imprecise. Also, the results of population admixture shows an overlap both in Euroasian and HG ancestry in East Africa without any further explanation of how it happened. The last part of the article is probably the most valuable one, since it shows the improvement of imputation accuracy of African populations variants by using different reference genome panel. Although finding the optimal array design for capturing most of African variation is admirable, in the current state of sequencing technology it might not be necessary anymore. A final remark is that the visualization of the results in extended and supplementary data was sometimes hard to decipher.