2 Matching Annotations
  1. Jul 2018
    1. On 2014 Dec 30, William Grant commented:

      Here are some papers not included in this review showing benefits of vitamin D testing. Peiris AN, Bailey BA, Grant WB, Mascitelli L. Vitamin D testing. Lancet 2012 May 5;379:1699-1701.

      Der T, Bailey BA, Youssef D, Manning T, Grant WB, Peiris AN.,Vitamin D and prostate cancer survival in veterans. Military Med. 2014;179 (1) :81–84.

      Peiris AN, Bailey BA, Manning T. Relationship of vitamin D monitoring and status to bladder cancer survival in veterans. South Med J. 2013 Feb;106(2):126-30.

      Bailey BA, Manning T, Peiris AN. Vitamin D testing patterns among six Veterans Medical Centers in the Southeastern United States: links with medical costs. Mil Med. 2012 Jan;177(1):70-6.

      Of course some may have been published after your literature search was completed. However, they do support the benefits of vitamin D testing among hospital patients.

      Also, this paper is supportive in that it found that patients in the ICU with very low 25OHD concentrations benefited from vitamin D supplementation. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A, Münch A, Warnkross H, Stojakovic T, Bisping E, Toller W, Smolle KH, Berghold A, Pieber TR, Dobnig H. Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency: The VITdAL-ICU Randomized Clinical Trial. JAMA. 2014 Oct 15;312(15):1520-30.

      One of the impediments to acceptance of vitamin D seems to be the lack of supportive trials. The trials have not supported the ecological and observational studies largely because the trials have not been properly designed. Too often, people with normal to high 25OHD concentrations are enrolled and given a small amount of vitamin D. The proper way to conduct such trials was outlined recently in this paper: Heaney RP. Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutr Rev. 2014 Jan;72(1):48-54.

      Disclosure I receive funding from Bio-Tech Pharmacal (Fayetteville, AR) and Medi-Sun Engineering, LLC (Highland Park, IL).


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.

  2. Feb 2018
    1. On 2014 Dec 30, William Grant commented:

      Here are some papers not included in this review showing benefits of vitamin D testing. Peiris AN, Bailey BA, Grant WB, Mascitelli L. Vitamin D testing. Lancet 2012 May 5;379:1699-1701.

      Der T, Bailey BA, Youssef D, Manning T, Grant WB, Peiris AN.,Vitamin D and prostate cancer survival in veterans. Military Med. 2014;179 (1) :81–84.

      Peiris AN, Bailey BA, Manning T. Relationship of vitamin D monitoring and status to bladder cancer survival in veterans. South Med J. 2013 Feb;106(2):126-30.

      Bailey BA, Manning T, Peiris AN. Vitamin D testing patterns among six Veterans Medical Centers in the Southeastern United States: links with medical costs. Mil Med. 2012 Jan;177(1):70-6.

      Of course some may have been published after your literature search was completed. However, they do support the benefits of vitamin D testing among hospital patients.

      Also, this paper is supportive in that it found that patients in the ICU with very low 25OHD concentrations benefited from vitamin D supplementation. Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A, Münch A, Warnkross H, Stojakovic T, Bisping E, Toller W, Smolle KH, Berghold A, Pieber TR, Dobnig H. Effect of High-Dose Vitamin D3 on Hospital Length of Stay in Critically Ill Patients With Vitamin D Deficiency: The VITdAL-ICU Randomized Clinical Trial. JAMA. 2014 Oct 15;312(15):1520-30.

      One of the impediments to acceptance of vitamin D seems to be the lack of supportive trials. The trials have not supported the ecological and observational studies largely because the trials have not been properly designed. Too often, people with normal to high 25OHD concentrations are enrolled and given a small amount of vitamin D. The proper way to conduct such trials was outlined recently in this paper: Heaney RP. Guidelines for optimizing design and analysis of clinical studies of nutrient effects. Nutr Rev. 2014 Jan;72(1):48-54.

      Disclosure I receive funding from Bio-Tech Pharmacal (Fayetteville, AR) and Medi-Sun Engineering, LLC (Highland Park, IL).


      This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.