On 2015 Jul 24, Miguel Lopez-Lazaro commented:

I agree with Dr. Baker that the SMT does not explain important aspects of the disease, and that new models of carcinogenesis should be explored. The “stem cell division theory of cancer” is a new model of carcinogenesis that integrates some features from existing theories (SMT, TOFT, and CSC model) and may provide a better framework for understanding the disease. It can explain, for instance, the cellular origin of cancer, the age distribution of the disease, the existence of metastatic cancers in the absence of primary tumors, or why a variety of factors that do not directly cause DNA alterations (e.g., mechanical, physical, chemical or neural factors) can induce cancer or modify cancer risk. http://www.ncbi.nlm.nih.gov/pubmed/26090957<br> http://www.ncbi.nlm.nih.gov/pubmed/26097879

On 2015 Jul 24, Miguel Lopez-Lazaro commented:

I agree with Dr. Baker that the SMT does not explain important aspects of the disease, and that new models of carcinogenesis should be explored. The “stem cell division theory of cancer” is a new model of carcinogenesis that integrates some features from existing theories (SMT, TOFT, and CSC model) and may provide a better framework for understanding the disease. It can explain, for instance, the cellular origin of cancer, the age distribution of the disease, the existence of metastatic cancers in the absence of primary tumors, or why a variety of factors that do not directly cause DNA alterations (e.g., mechanical, physical, chemical or neural factors) can induce cancer or modify cancer risk. http://www.ncbi.nlm.nih.gov/pubmed/26090957<br> http://www.ncbi.nlm.nih.gov/pubmed/26097879