- Jul 2018
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europepmc.org europepmc.org
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On 2015 Nov 23, Amanda Capes-Davis commented:
MA-1, one of the cell lines used in this study, is misidentified and corresponds to Pfeiffer. MA-1 was originally thought to come from MALT lymphoma. As a derivative of Pfeiffer, MA-1 is actually derived from diffuse large B-cell lymphoma.
A letter has been published in Genes, Chromosomes & Cancer on the origin of MA-1. Please refer to http://www.ncbi.nlm.nih.gov/pubmed/23907998 for more information.
It should be noted that the authors refer to MA-1 broadly as a lymphoma cell line, which is true as far as it goes. So the question could well be asked: how much information needs to be given where the authenticity of a cell line has been called into question?
This paper is focused on potential therapies for MALT lymphoma, amongst other lymphoma types, and examines both MA-1 and Pfeiffer. The origin of the cell line is therefore relevant, and a lack of transparency regarding the origin of the cell line may be misleading to the reader.
Transparency could be much improved here by stating that MA-1 is a derivative of Pfeiffer and reporting the revised tissue of origin.
A list of known misidentified cell lines is curated by the International Cell Line Authentication Committee (ICLAC) and can be found at http://iclac.org/databases/cross-contaminations/.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2015 Nov 23, Amanda Capes-Davis commented:
MA-1, one of the cell lines used in this study, is misidentified and corresponds to Pfeiffer. MA-1 was originally thought to come from MALT lymphoma. As a derivative of Pfeiffer, MA-1 is actually derived from diffuse large B-cell lymphoma.
A letter has been published in Genes, Chromosomes & Cancer on the origin of MA-1. Please refer to http://www.ncbi.nlm.nih.gov/pubmed/23907998 for more information.
It should be noted that the authors refer to MA-1 broadly as a lymphoma cell line, which is true as far as it goes. So the question could well be asked: how much information needs to be given where the authenticity of a cell line has been called into question?
This paper is focused on potential therapies for MALT lymphoma, amongst other lymphoma types, and examines both MA-1 and Pfeiffer. The origin of the cell line is therefore relevant, and a lack of transparency regarding the origin of the cell line may be misleading to the reader.
Transparency could be much improved here by stating that MA-1 is a derivative of Pfeiffer and reporting the revised tissue of origin.
A list of known misidentified cell lines is curated by the International Cell Line Authentication Committee (ICLAC) and can be found at http://iclac.org/databases/cross-contaminations/.
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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