On 2015 Apr 18, Dorothy V M Bishop commented:

This is an impressive paper in terms of sample size for those with aneuploidies, and the results are intriguing and important. It is particularly surprising that the asymmetries in the XXY group look so normal, when –as the authors point out - the one functional study on this group found strikingly reduced functional asymmetry in the Superior Temporal Gyrus (van Rijn et al, 2008). As the authors note, the links between functional and structural asymmetries are far from clear, and this study provides further motivation for doing studies that contrast the two.

I have just one niggling criticism, which is that the authors cite Sun et al as evidence for early asymmetric gene expression in humans. I don't think that the data from Sun et al support their conclusions, and I've explained why in a comment on PubMed Commons. http://www.ncbi.nlm.nih.gov/pubmed?term=Early asymmetry of gene transcription in embryonic human left and right cerebral cortex

On 2015 Apr 18, Dorothy V M Bishop commented:

This is an impressive paper in terms of sample size for those with aneuploidies, and the results are intriguing and important. It is particularly surprising that the asymmetries in the XXY group look so normal, when –as the authors point out - the one functional study on this group found strikingly reduced functional asymmetry in the Superior Temporal Gyrus (van Rijn et al, 2008). As the authors note, the links between functional and structural asymmetries are far from clear, and this study provides further motivation for doing studies that contrast the two.

I have just one niggling criticism, which is that the authors cite Sun et al as evidence for early asymmetric gene expression in humans. I don't think that the data from Sun et al support their conclusions, and I've explained why in a comment on PubMed Commons. http://www.ncbi.nlm.nih.gov/pubmed?term=Early asymmetry of gene transcription in embryonic human left and right cerebral cortex