- Jul 2018
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europepmc.org europepmc.org
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On 2015 Jan 23, Madhusudana Girija Sanal commented:
The Cancer Stem Cell-Bauble!
Does cancer stem cell exist after all? Yes or no because the definition is in the eye of the beholder! Cancer is well defined, stem cells are well defined, but cancer stem cell is unfortunately not the sum of these two and that is where it is poorly defined. Protein markers will come and go on the surface or inside. Currently it is like the definition of beauty or social justice! After all (most, if not all) cancers are a dynamic state of cells with respect to their epigenetic and genetic status during their course of evolution, selection and survival. So, what is NOT a cancer-non-stem cell today can become cancer stem cell tomorrow and vice versa detected by the micro and macro environment and the evolutionary pressure. Cells which have a "very loose" epigenetic stability (on a background of one or more 'oncogene' mutations) are the ideal candidates for cancer "stem" cell. This may be a better definition for those who really want to see that cancer stem cells do exist and the see that concept of cancer stem cells survive! Or wait for the bubble to burst!
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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- Feb 2018
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europepmc.org europepmc.org
-
On 2015 Jan 23, Madhusudana Girija Sanal commented:
The Cancer Stem Cell-Bauble!
Does cancer stem cell exist after all? Yes or no because the definition is in the eye of the beholder! Cancer is well defined, stem cells are well defined, but cancer stem cell is unfortunately not the sum of these two and that is where it is poorly defined. Protein markers will come and go on the surface or inside. Currently it is like the definition of beauty or social justice! After all (most, if not all) cancers are a dynamic state of cells with respect to their epigenetic and genetic status during their course of evolution, selection and survival. So, what is NOT a cancer-non-stem cell today can become cancer stem cell tomorrow and vice versa detected by the micro and macro environment and the evolutionary pressure. Cells which have a "very loose" epigenetic stability (on a background of one or more 'oncogene' mutations) are the ideal candidates for cancer "stem" cell. This may be a better definition for those who really want to see that cancer stem cells do exist and the see that concept of cancer stem cells survive! Or wait for the bubble to burst!
This comment, imported by Hypothesis from PubMed Commons, is licensed under CC BY.
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