On 2015 Jan 26, David D Leedahl commented:

We appreciate this comment. The patient had an extensive list of allergies to antimicrobials, which included multiple beta lactams (penicillin, ertapenem, aztreonam) in addition to several additional antibiotics from other classes. The decision to initiate a desensitization protocol to ceftaroline on the general medical floor outweighed the risk of potentially inducing an allergic reaction. Whether or not the patient would have experienced an allergic reaction to ceftaroline without completing a desensitization protocol, we agree, is uncertain.

On 2015 Jan 20, Eric Macy commented:

An IgE-mediated allergy to ceftaroline was not confirmed in this patient by either skin testing or challenge. Only a very small minority of even clinically significant penicillin allergy confirmed individuals will have IgE-mediated reactions to any specific cephalosporin. Only a small minority of individuals with multiple drug intolerance syndrome have any underlying IgE-mediated allergy to any of the medications they have noted reactions associated with.

On 2015 Jan 20, Eric Macy commented:

An IgE-mediated allergy to ceftaroline was not confirmed in this patient by either skin testing or challenge. Only a very small minority of even clinically significant penicillin allergy confirmed individuals will have IgE-mediated reactions to any specific cephalosporin. Only a small minority of individuals with multiple drug intolerance syndrome have any underlying IgE-mediated allergy to any of the medications they have noted reactions associated with.

On 2015 Jan 26, David D Leedahl commented:

We appreciate this comment. The patient had an extensive list of allergies to antimicrobials, which included multiple beta lactams (penicillin, ertapenem, aztreonam) in addition to several additional antibiotics from other classes. The decision to initiate a desensitization protocol to ceftaroline on the general medical floor outweighed the risk of potentially inducing an allergic reaction. Whether or not the patient would have experienced an allergic reaction to ceftaroline without completing a desensitization protocol, we agree, is uncertain.