On 2017 May 04, Jeremy Horst commented:

Can the actual results of this study be extended to infer a role of human genes in the disease? The influence of sex on the relationship to and influence of the environment is known to be strong for this disease. No assessment of any genotype besides assumed XX vs XY was performed.

Also, a role for horizontal transmission of dental plaque bacteria from parents to children has been established. This obfuscates simple heritability estimates.

Are there any loci that have shown an association with disease or disease severity in different studies? Perhaps lactoferrin. Clearly there is a role when tooth-development genes are mutated, but these are rare and do not extend to the general population.

The conclusions here go to far in purporting genes as the cause of the difference in disease outcomes by sex.

On 2017 May 04, Jeremy Horst commented:

Can the actual results of this study be extended to infer a role of human genes in the disease? The influence of sex on the relationship to and influence of the environment is known to be strong for this disease. No assessment of any genotype besides assumed XX vs XY was performed.

Also, a role for horizontal transmission of dental plaque bacteria from parents to children has been established. This obfuscates simple heritability estimates.

Are there any loci that have shown an association with disease or disease severity in different studies? Perhaps lactoferrin. Clearly there is a role when tooth-development genes are mutated, but these are rare and do not extend to the general population.

The conclusions here go to far in purporting genes as the cause of the difference in disease outcomes by sex.