On 2015 Apr 13, Joe Newton commented:

Major depression diagnosis in the absence of preexisting biomarkers is uncertain and a dilemma of psychiatry. However, measurable biomarkers of intracranial volumes are suggested by the large genetic and imaging consortium studies. (Stein JL, et al. 2012 Nat Genet. Apr 15;44(5):552-61). Nevertheless your paper is unusually interesting in suggesting ECT induced hippocampal volumes.<br> I have wondered for decades about how ECT improves nervous system coordination in a broad spectrum of abnormal behavioral responses.<br> Best wishes, Joe Ray Newton

On 2015 Apr 13, Joe Newton commented:

Major depression diagnosis in the absence of preexisting biomarkers is uncertain and a dilemma of psychiatry. However, measurable biomarkers of intracranial volumes are suggested by the large genetic and imaging consortium studies. (Stein JL, et al. 2012 Nat Genet. Apr 15;44(5):552-61). Nevertheless your paper is unusually interesting in suggesting ECT induced hippocampal volumes.<br> I have wondered for decades about how ECT improves nervous system coordination in a broad spectrum of abnormal behavioral responses.<br> Best wishes, Joe Ray Newton