On 2016 Mar 12, Kjartan Vaarbakken commented:

Thanks for your enourmous effort undertaking this review on laser therapy for knee osteoarthritis (OA).

In an attempt to add some to the discussion by looking for dose-response relationships, I suggest that laser with continuous output of 100 to 800 mW, energy density of 48 to 50 J/cm2, and energy per point of 6 J - all performed 2 times a week - may be the thing to try in the next laser trial on knee OA? Maybe the World Association of Laser Therapy guideline has underestimated the energy needed to effectively treat an osteoarthritic knee joint? Or maybe there is deeper tissues within the joint being reached by putting in more light energy? As cartilage and bone? Or, the fact that higher laser doses is needed for anti-inflammatory effects, a high energy deliverance may be the right stimuli to impair a synovial inflammation?

Please take a look at this link supposed to illustrate a possible dose-respons relationship: https://twitter.com/kvaarbakken/status/708593031998533634

Best regards, Kjartan Vaarbakken Physiotherapist, MSc, PhD student Norwegian University of Science and Technology Trondheim, Norway http://www.ntnu.edu/employees/kjartan.varbakken

On 2016 Mar 12, Kjartan Vaarbakken commented:

Thanks for your enourmous effort undertaking this review on laser therapy for knee osteoarthritis (OA).

In an attempt to add some to the discussion by looking for dose-response relationships, I suggest that laser with continuous output of 100 to 800 mW, energy density of 48 to 50 J/cm2, and energy per point of 6 J - all performed 2 times a week - may be the thing to try in the next laser trial on knee OA? Maybe the World Association of Laser Therapy guideline has underestimated the energy needed to effectively treat an osteoarthritic knee joint? Or maybe there is deeper tissues within the joint being reached by putting in more light energy? As cartilage and bone? Or, the fact that higher laser doses is needed for anti-inflammatory effects, a high energy deliverance may be the right stimuli to impair a synovial inflammation?

Please take a look at this link supposed to illustrate a possible dose-respons relationship: https://twitter.com/kvaarbakken/status/708593031998533634

Best regards, Kjartan Vaarbakken Physiotherapist, MSc, PhD student Norwegian University of Science and Technology Trondheim, Norway http://www.ntnu.edu/employees/kjartan.varbakken