On 2015 Aug 24, Martine Crasnier-Mednansky commented:

Relevant published data were not taken into consideration by the authors, as indicated below.

In 2007, Vibrio fischeri was reclassified as Aliivibrio fischeri Urbanczyk H, 2007.

Transcription of the cpdA gene, encoding the cellular cAMP phosphodiesterase CpdA, is positively regulated by the CRP-cAMP complex, as reported for the closely related Vibrio vulnificus cpdA gene Kim HS, 2009. By itself, this finding infers homeostatic control of the cAMP cellular concentration by CpdA in A. fischeri. This is reminiscent of Pseudomonas aeruginosa CpdA whose gene transcription is also under cAMP positive control Fuchs EL, 2010.

As regards the periplasmic cAMP phosphodiesterase CpdP, Dunlap PV, 1993 reported its specific activity was 'exceptionally' high, and allowed growth on cAMP as the sole source of carbon and energy. Therefore the role of CpdP in altering the periplasmic cAMP concentration in A. fischeri is important and, as shown by data in figure 4A, likely regulates indirectly the cytoplasmic cAMP concentration by controlling excretion of cAMP from the cell.

On 2015 Aug 24, Martine Crasnier-Mednansky commented:

Relevant published data were not taken into consideration by the authors, as indicated below.

In 2007, Vibrio fischeri was reclassified as Aliivibrio fischeri Urbanczyk H, 2007.

Transcription of the cpdA gene, encoding the cellular cAMP phosphodiesterase CpdA, is positively regulated by the CRP-cAMP complex, as reported for the closely related Vibrio vulnificus cpdA gene Kim HS, 2009. By itself, this finding infers homeostatic control of the cAMP cellular concentration by CpdA in A. fischeri. This is reminiscent of Pseudomonas aeruginosa CpdA whose gene transcription is also under cAMP positive control Fuchs EL, 2010.

As regards the periplasmic cAMP phosphodiesterase CpdP, Dunlap PV, 1993 reported its specific activity was 'exceptionally' high, and allowed growth on cAMP as the sole source of carbon and energy. Therefore the role of CpdP in altering the periplasmic cAMP concentration in A. fischeri is important and, as shown by data in figure 4A, likely regulates indirectly the cytoplasmic cAMP concentration by controlling excretion of cAMP from the cell.