On 2016 Feb 21, Joe Newton commented:

This revealing study, in the absence of established biological markers, and gene sequencing for epistasis, highlights the diagnostic dilemma of uncertainty of animal control systems. For example, "The diagnosis of schizophrenia was made with great rigor by obtaining a consensus between clinical diagnosis of an expert clinician and a research diagnosis generated by MINI-Plus interview. Moreover, diagnostic stability over 1–3 years was examined by reviewing the follow-up notes; ten subjects were excluded from the final sample following this exercise." In addition, the cohort sample size (45 each) is likely too small.

Statistical method, although following established procedures, is also uncertain for a many degree-of-freedom simultaneous non-linear system. For example, the null HYPOTHESIS, based on smooth Gaussian curves, applied to such a system, is questionable.

Congratulations to the authors. Joe Ray Newton

On 2016 Feb 21, Joe Newton commented:

This revealing study, in the absence of established biological markers, and gene sequencing for epistasis, highlights the diagnostic dilemma of uncertainty of animal control systems. For example, "The diagnosis of schizophrenia was made with great rigor by obtaining a consensus between clinical diagnosis of an expert clinician and a research diagnosis generated by MINI-Plus interview. Moreover, diagnostic stability over 1–3 years was examined by reviewing the follow-up notes; ten subjects were excluded from the final sample following this exercise." In addition, the cohort sample size (45 each) is likely too small.

Statistical method, although following established procedures, is also uncertain for a many degree-of-freedom simultaneous non-linear system. For example, the null HYPOTHESIS, based on smooth Gaussian curves, applied to such a system, is questionable.

Congratulations to the authors. Joe Ray Newton