On 2015 Aug 26, Jim Woodgett commented:

I sound like a broken record, but it is quite remarkable that yet another paper presumes an inhibitor is specific for GSK-3beta. In this case (AR-A014418) is equally as effective at inhibiting GSK-3alpha, as is every other small molecule inhibitor of GSK-3, including lithium. This is a problem because the authors fail to assess the contribution of the second isoform which is being equivalently blocked in the experiments. There are numerous papers that describe the common and distinctive functions of these protein kinases.

On 2015 Aug 26, Jim Woodgett commented:

I sound like a broken record, but it is quite remarkable that yet another paper presumes an inhibitor is specific for GSK-3beta. In this case (AR-A014418) is equally as effective at inhibiting GSK-3alpha, as is every other small molecule inhibitor of GSK-3, including lithium. This is a problem because the authors fail to assess the contribution of the second isoform which is being equivalently blocked in the experiments. There are numerous papers that describe the common and distinctive functions of these protein kinases.