On 2015 Sep 01, Friedrich Thinnes commented:

From my point of view the dust-raising effect of antibody 6E10 fuels the idea that plasmalemma-integrated VDAC-1 works as a receptor of amyloid Aß.

It has been shown that docking of amyloid Aß via GxxxG motif interaction to cell membrane-standing VDAC-1 opens the channel, and this way induces neuronal cell deaths accumulating over time.

Whenever critical brain regions and all redundant structures are affected Alzheimer´s Dementia appears.

For details see Friedrich P. Thinnes, Biochimica et Biophysica Acta 1848 (2015) 1410–1416 and www.futhin.de

On 2015 Sep 01, Friedrich Thinnes commented:

From my point of view the dust-raising effect of antibody 6E10 fuels the idea that plasmalemma-integrated VDAC-1 works as a receptor of amyloid Aß.

It has been shown that docking of amyloid Aß via GxxxG motif interaction to cell membrane-standing VDAC-1 opens the channel, and this way induces neuronal cell deaths accumulating over time.

Whenever critical brain regions and all redundant structures are affected Alzheimer´s Dementia appears.

For details see Friedrich P. Thinnes, Biochimica et Biophysica Acta 1848 (2015) 1410–1416 and www.futhin.de