On 2016 Apr 16, Miguel Lopez-Lazaro commented:

Important flaws in the identification of the cells of origin in cancer

This is an extension of this Editorial (Cancer arises from stem cells: opportunities for anticancer drug discovery) and a commentary on the article http://www.ncbi.nlm.nih.gov/pubmed/27044116

Abstract: The cells of origin in cancer are the cells in which carcinogenesis starts, i.e., the normal cells that acquire the first cancer-related hit. These cells should not be confused with the cancer stem cells or tumor-initiating cells, which are malignant cells with the ability to initiate and maintain tumor growth. Recently, many articles published in leading journals claim that they have experimentally demonstrated the cellular origin of several types of cancer. These articles, however, have important flaws that may have led to wrong conclusions. Here I briefly discuss one of the many articles in this field of research to draw attention to these flaws. In addition, I analyze the striking differences in prostate cancer incidence by age to examine the article’s conclusion and to propose that prostate cancer originates in stem cells. The striking variations in cancer risk among tissues also indicate that stem cells are the cells of origin in cancer.

Full text at: Lopez-Lazaro, M. Important flaws in the identification of the cells of origin in cancer. ResearchGate: DOI: 10.13140/RG.2.1.4321.5769; http://dx.doi.org/10.13140/RG.2.1.4321.5769

On 2016 Apr 16, Miguel Lopez-Lazaro commented:

Important flaws in the identification of the cells of origin in cancer

This is an extension of this Editorial (Cancer arises from stem cells: opportunities for anticancer drug discovery) and a commentary on the article http://www.ncbi.nlm.nih.gov/pubmed/27044116

Abstract: The cells of origin in cancer are the cells in which carcinogenesis starts, i.e., the normal cells that acquire the first cancer-related hit. These cells should not be confused with the cancer stem cells or tumor-initiating cells, which are malignant cells with the ability to initiate and maintain tumor growth. Recently, many articles published in leading journals claim that they have experimentally demonstrated the cellular origin of several types of cancer. These articles, however, have important flaws that may have led to wrong conclusions. Here I briefly discuss one of the many articles in this field of research to draw attention to these flaws. In addition, I analyze the striking differences in prostate cancer incidence by age to examine the article’s conclusion and to propose that prostate cancer originates in stem cells. The striking variations in cancer risk among tissues also indicate that stem cells are the cells of origin in cancer.

Full text at: Lopez-Lazaro, M. Important flaws in the identification of the cells of origin in cancer. ResearchGate: DOI: 10.13140/RG.2.1.4321.5769; http://dx.doi.org/10.13140/RG.2.1.4321.5769